Concepedia

Targeted cancer cell inhibition using multifunctional dendrimer-entrapped gold nanoparticles

Linfeng Zheng, Jingyi Zhu, Mingwu Shen, Xisui Chen, James R. Baker, Su He Wang, Guixiang Zhang, Xiangyang Shi

MedChemComm · 2013 · 40 citations · 37 references

DOI

Concepts

Abstract

Generation 5-poly(amidoamine) dendrimers pre-modified with folic acid and methotrexate (G5-FA-MTX) were used as templates for the synthesis of dendrimer-entrapped gold nanoparticles (Au DENPs). The synthesized [(Au0)50-G5-FA-MTX] DENPs were able to target and specifically inhibit the growth of cancer cells overexpressing high affinity folic acid receptors.

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