Journal of Medicinal Chemistry · 1987 · 39 citations · 0 references
MedicineMedicinal ChemistryPharmacologyMolecular PharmacologyNeuropharmacologyStructure-activity RelationshipsDrug ReceptorsDrug-receptor InteractionsLigand BindingReceptor PharmacologyReceptor-ligand InteractionsStructure-activity Relationship AnalysisBenzodiazepine Binding SitesBenzodiazepine Receptor AgonistsDrug - Membrane InteractionsDrug Receptor PharmacologyQuinoline ChemistryQuinoline Synthesis
A series of 1,3-diarylpyrazolo[4,5-c]- and -[5,4-c]quinolin-4-ones were prepared and tested for their ability to displace [3H]flunitrazepam from bovine brain membranes. While the 1,3-diarylpyrazolo[4,5-c]quinoline derivatives showed affinity for the receptor site, their [5,4-c] isomers were devoid of binding activity.