Receptor‐Specific Delivery of Protein Antigen to Dendritic Cells by a Nanoemulsion Formed Using Top‐Down Non‐Covalent Click Self‐Assembly

Abstract

A new class of targeted and immune-evading nanocarrier made using only biological components and facile processes is assembled in a bottom-up fashion. Simple top-down sequential addition of immune-evading or receptor-specific antibody elements conjugated to biosurfactant protein DAMP4 promotes self-assembly at an interface previously formed in the presence of peptide surfactant AM1, leading to a functional display at the interface through non-covalent molecular self-assembly.