Increased neocortical expression of the <scp>P</scp>2X7 receptor after status epilepticus and anticonvulsant effect of <scp>P</scp>2X7 receptor antagonist <scp>A</scp>‐438079

Abstract

Our findings identify neurons in the neocortex as an important site of P2X7R up-regulation after status epilepticus and in epilepsy, and provide support for the possible use of P2X7R antagonists for the treatment of status epilepticus and prevention of seizure-induced brain damage.