Analysis of<i>CFH</i>,<i>TLR4</i>, and<i>APOE</i>Polymorphism in India Suggests the Tyr402His Variant of<i>CFH</i>to be a Global Marker for Age-Related Macular Degeneration - Concepedia

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Analysis of<i>CFH</i>,<i>TLR4</i>, and<i>APOE</i>Polymorphism in India Suggests the Tyr402His Variant of<i>CFH</i>to be a Global Marker for Age-Related Macular Degeneration

84

Citations

40

References

2006

Year

Inderjeet Kaur, Avid Hussain, Nazimul Hussain, Taraprasad Das, Avinash Pathangay, Annie Mathai, Anjli Hussain, Rishita Nutheti, Praveen K. Nirmalan, Subhabrata Chakrabarti

Investigative Ophthalmology & Visual Science

Abstract

The CFH polymorphism Tyr402His appears indicative of AMD pathogenesis. Diabetes, age, and gender in the presence of the homozygous "CC" genotype in CFH carry an increased risk of AMD. Hence this polymorphism could be used as a potential marker for predictive testing across continents.

References

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