A Concise Asymmetric Route to the Bridged Bicyclic Tropane Alkaloid Ferruginine Using Enyne Ring-Closing Metathesis

Abstract

[reaction: see text] Enyne metathesis has been used to prepare bridged azabicycles and applied in a short asymmetric synthesis of the tropane ferruginine. A Grubbs first generation catalyst proved to be superior to the second generation catalyst in the enyne metathesis reaction.