Cross-sectional study of the susceptibility of Candida isolates to antifungal drugs and in vitro–in vivo correlation in HIV-infected patients

Abstract

Oral candidiasis and fluconazole-resistant Candida isolates are more frequently found in IVDU. Treatments using azoles select non-albicans strains and are associated with decreased susceptibilities of C. albicans strains to fluconazole in particular. These findings show that prolonged azole treatment in severely immunocompromised patients should be avoided.