Effects of Galanin on Hormone Secretion from the in Situ Perfused Rat Pancreas and on Glucose Productionin Rat Hepatocytes<i>in Vitro</i>*

Abstract

in the perfused rat pancreas, galanin inhibited insulin secretion without modifying glucagon and somatostatin output, thus pointing to a direct effect of galanin on the B cell; and in rat hepatocytes, galanin did not affect glycogenolysis or gluconeogenesis; hence, the reported hyperglycemia induced by exogenous galanin does not seem to be accounted for by a direct effect of this peptide on hepatic glucose production.