Synthetic inhibitors of Escherichia coli, calf thymus, and Ehrlich ascites tumor thymidylate synthetase

Abstract

Since none of the commercially available nano- or ultrafiltration membranes so far shows real long-term resistance against organic solvents under the reaction conditions needed for a commercially interesting hydroformylation process and since no prices are available for bulk quantities of membranes for larger scale applications, considerations about the feasibility of such processes are difficult and would be highly speculative.\n \nHowever, with the combined arguments of process intensification due to simultaneous product and catalyst separation, increased product purity, and the reaction engineering advantages provided by a continuous homogeneous catalysis, a rapid development can be foreseen. A lot more fundamental work is needed in order to underline the applicability, together with the development of new membrane materials showing better performance. This field is an ideal example of multidisciplinary research in which contributions from many fields is a prerequisite for success. The availability of larger quantities of solvent resistant membranes will be driven by a strong technology push in the near future.