Dhilirolides A−D, Meroterpenoids Produced in Culture by the Fruit-Infecting Fungus <i>Penicillium purpurogenum</i> Collected in Sri Lanka

Abstract

Dhilirolides A (1) to D (4), a family of secondary metabolites with a putative meroterpenoid biogenetic origin and the unprecedented dhilirane and isodhilirane carbon skeletons, have been isolated from laboratory cultures of the fruit-infecting fungus Penicillium purpurogenum collected in Sri Lanka. The structures of 1 to 4 were elucidated by interpretation of NMR data and a single crystal X-ray diffraction analysis of 1.