Treatment of Infections in Man With Cephalothin

Abstract

Cephalothin, a semisynthetic derivative of cephalosporanic acid, was used successfully to treat 77 of 80 infections. Therapy was successful against<i>Staphylococcus aureus, Streptococcus, Diplococcus pneumoniae, Escherichia coli, Clostridium perfringens, Aerobacter aerogenes</i>, mixed<i>Proteus mirabilis, Str faecalis</i>, and mixed<i>Staph aureus</i>and group A<i>Str pyogenes</i>infections. Miliary tuberculosis,<i>Hemophilus influenzae</i>meningitis, and vaccinia failed to respond. No cross-sensitivity between cephalothin and penicillin could be documented, suggesting that cephalothin is an effective parenteral antibacterial agent for infections produced by penicillin G-sensitive and resistant staphylococci, pneumococci, streptococci, possibly<i>C1 perfringens</i>, and selected gram-negative enteric bacteria.