Edaravone directly reacts with singlet oxygen and protects cells from attack

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Tim R. Mosmann · Journal of Immunological Methods · 1983 · 54.9K citations

Cellular Growth, Rapid Colorimetric Assay, Cytotoxicity Assays +11

Effect of a Novel Free Radical Scavenger, Edaravone (MCI-186), on Acute Brain Infarction

Cerebrovascular Diseases · 2003 · 660 citations

Edaravone Group, Cerebrovascular Disease, Cerebral Vascular Regulation +19

Imaging the production of singlet oxygen in vivo using a new fluorescent sensor, Singlet Oxygen Sensor Green(R)

Cristina Flors · Journal of Experimental Botany · 2006 · 494 citations · Full text

Molecular Biology, Biomedical Engineering, New Fluorescent Sensor +19

Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions.

Toshiaki Watanabe, Satoshi Yuki, Mariko Egawa et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 463 citations

Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy

Partha Mukhopadhyay, Mohanraj Rajesh, György Haskó et al. · Nature Protocols · 2007 · 363 citations · Full text

Flow Cytometry, Mitochondrial Function, Biochemistry +8