European Journal of Organic Chemistry · 2007 · 38 citations · 18 references
Natural SciencesBiochemistryMarine SciencesMarine BiodiversityMass Spectrometric AnalysisProtein BiochemistryAmino Acid ChemistryMarine Bioactive CompoundsMarine Natural ProductsPeptide AnalysisPeptide ChemistryPeptide IdentificationAbsolute Configuration AssignmentAbsolute Configuration DeterminationBioactive Compounds From Marine SpongesBioactive Marine MetabolitesBioactive Marine PeptidesMarine Sponge MetabolitesSponges-derived MetabolitesStructure Elucidation Of Marine Natural Products
Abstract Four new cyclic heptapeptides, stylissamides A–D ( 1 – 4 ), were isolated from the Caribbean sponge Stylissa caribica . The structures of these metabolites were elucidated by NMR and MS/MS methods. The peptides contain three and, in one case, four proline residues. The sequence assignment of 1 – 4 by NMR was supported by fragmentations in HR‐MS/MS measurements. The absolute configuration of all amino acid residues was assigned as L using Marfey's method and the OPA method.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
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