A Role for Interleukin‐10 in Alcohol‐Induced Liver Sensitization to Bacterial Lipopolysaccharide

Abstract

Alcohol-induced liver sensitization to LPS in wild-type mice may involve down-regulation of IL-10. This anti-inflammatory cytokine, known for its hepatoprotective effects, is secreted simultaneously with proinflammatory cytokines. IL-10 may also limit alcohol-induced liver damage by counteracting the effects of proinflammatory cytokines.