Zeitschrift für anorganische und allgemeine Chemie · 2001 · 31 citations · 0 references
Natural SciencesChemistryMedicinal ChemistryNucleic Acid ChemistryOrganometallic ChemistrySynthetic Medicinal ChemistryCoordination ChemistryLigand BindingMetal-ligand BondingNucleobase ChemistryTransition Metal ChemistryTransition Metal ComplexesChelation StudiesComplexation ChemistryMetalloid ComplexesPlatinum CompoundsSpectroscopic Characterization Of Metal-ligand BondsSynthetic NucleobasesX-ray Diffraction AnalysisX-ray Structure Determination
The reactions of [Pt(dpma)(H2O)2]2+ (dpma = 2,2′-dipyridylmethylamine) and [Pt(dpk)(H2O)2]2+ (dpk = 2,2′-dipyridylketone) with the model nucleobases 1-methylthymine (1-MeT) and 1-methyluracil (1-MeU) were studied. Reaction products were characterized by 195Pt NMR spectroscopy and by X-ray structure analysis. The symmetric dpma and dpk diaqua complexes form dinuclear complexes with 1-methylthymine, acting as secondary bridging ligand via its N3 and O4 donor atoms. [Pt2(dpma)2(1-MeT)2](ClO4)2 · H2O (5) and [Pt2(dpk)(dpk · H2O)(1-MeT)2](PF6)2 · 4 H2O (6) both show a head-to-head arrangement. Biological tests show a significant in vitro antitumor activity of [Pt(dpk)Cl2] against the human glioma cell line U 87.