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Lewis Acid-Catalyzed Cyclization of Enaminones with Propargylic Alcohols: Regioselective Synthesis of Multisubstituted 1,2-Dihydropyridines
67
Citations
48
References
2013
Year
Cross-coupling ReactionLewis Acid-catalyzed CyclizationEngineeringHeterocyclicMultisubstituted 1,2-DihydropyridinesNatural SciencesDiversity-oriented SynthesisPropargylic AlcoholsOrganic ChemistryCatalysisChemistryRegioselective AccessEnantioselective SynthesisBiomolecular EngineeringMild Reaction Conditions
A highly efficient BF3·Et2O-catalyzed cascade reaction of enaminones with propargylic alcohols under mild reaction conditions has been developed. This methodology offers regioselective access to multisubstituted 1,2-dihydropyridines in good to excellent yields.
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