The Journal of Organic Chemistry · 2006 · 40 citations · 3 references
Bioorganic ChemistryEngineeringBiochemistryRegioselective 6-Endo CyclizationsNatural SciencesOlivacine Skeleton2-Indolylacyl RadicalsTotal SynthesisOrganic ChemistryStraightforward Synthetic EntryHeterocycle ChemistryPharmacologySynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringNatural Product Synthesis
A regioselective 6-endo reductive cyclization of 2-indolylacyl radicals constitutes the key step of a straightforward synthetic entry to the olivacine skeleton, illustrated by a total synthesis of the tetrahydropyridine alkaloid guatambuine.
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