Journal of Reconstructive Microsurgery · 1996 · 61 citations · 0 references
MedicineNeuroscienceSurgeryPeripheral Nerve SurgeryRegenerative MedicineTissue EngineeringNerve ReconstructionNerve RegenerationNerve RepairNervous TissueNeural RegenerationSchwann Cell BiologyControl Group DesignMatched Control GroupNerve Conduction VelocityNerve Conduit RepairNerve Gap ReconstructionPeripheral Nerve RegenerationPolyglycolic AcidSchwann Cell-mediated Repair
A 3-cm peripheral nerve gap in a rabbit hind-limb model was repaired by using a polyglycolic acid (PGA) conduit filled with a gelatin/Schwann-cell suspension. Postoperative nerve function after 16 weeks, as measured by isometric twitch and tetanic muscle strengths, and nerve conduction velocities, failed to demonstrate a statistically significant difference, compared to a control group in which the nerve gap was reconstructed by using a PGA conduit filled with gelatin only. The 3-cm gap in the described model may not have been long enough to show a significant difference between the two groups. Alternatively, the transferred cultured Schwann cells may have been functionally inactive.