Impact of Immunosuppressants on the Therapeutic Efficacy of In Vitro-Expanded CD4+CD25+Foxp3+ Regulatory T Cells in Allotransplantation

Abstract

These results demonstrate that inhibition of CD40-CD40L interaction or treatment with rapamycin could be successfully combined with in vitro-expanded Treg cell therapy, but the concomitant use of mycophenolate mofetil or cyclosporine A in this type of Treg cell therapy should be carefully considered.