Intra‐articular zoledronic acid in a rat osteoarthritis model: significant reduced synovitis may indicate chondroprotective effect

Abstract

Intra- articular zoledronic acid may suppress synovial inflammation. Furthermore, Zoledronic Acid does not reduce cartilage degeneration in early osteoarthritis models, but may provide some chondroprotective effect in ACLT- induced knee osteoarthritis model in rats.