Pd-Catalyzed Three-Component Coupling of <i>N</i>-Tosylhydrazone, Terminal Alkyne, and Aryl Halide

Abstract

A Pd-catalyzed three-component reaction of N-tosylhydrazone, terminal alkyne, and aryl halide follows a mechanism involving a sequence of Pd carbene migratory insertion-transmetalation-reductive elimination, leading to the formation of one sp(2)-sp(3) C-C bond and one sp-sp(3) C-C bond.