The Dynamics of Vascular Volume and Fluid Shifts of Lactated Ringer’s Solution and Hypertonic-Saline-Dextran Solutions Infused in Normovolemic Sheep

Abstract

Hypertonic saline dextran (HSD) is a new plasma expander recently approved for clinical use in Europe. We compared the plasma volume expansion of HSD versus lactated Ringers (LR) in normovolemic sheep. After a 30 min infusion, HSD was 7 times as effective at expanding volume as an equal volume of LR, but for the next 90 minutes the relative effectiveness of HSD increased to 10-20 times.