Dendrite Remodeling and Other Abnormalities in the Retinal Ganglion Cells of Ins2^AkitaDiabetic Mice

Abstract

The data show that retinal ganglion cells are lost from the peripheral retina of mice within the first 3 months of diabetes and that the dendrites of surviving large ON-type cells undergo morphologic changes. These abnormalities may explain some of the early anomalies in visual function induced by diabetes.