Bulletin of the Chemical Society of Japan · 1983 · 50 citations · 13 references
Natural SciencesChemistryCatalysisOrganic ChemistryReaction EngineeringCatalyst PreparationCatalytic MechanismsHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisSupported CatalystsAlkylation CatalysisAlkylation ProcessesAlkylation ReactionsIndole ChemistryMild Reaction ConditionsPhase-transfer CatalysisPhase-transfer CatalystsQuaternary Ammonium Compounds
Abstract The alkylation of pyrrole and indole in aqueous potassium hydroxide-organic two-phase systems in the presence of polyethylene glycols (PEG) or their dialkyl ethers (PEG-ether) as phase transfer catalysts (PTC) gave substantial quantities of the C-alkylated and C,N-polyalkylated products as well as the N-alkylated products. This fact is similar to that obtained in the presence of quaternary ammonium salts as PTC. In powdered potassium hydroxide-organic two-phase systems, the yields of the N-alkylated products were generally high. Especially, when PEG-ether were employed as solvents, the N-alkylated products were obtained in excellent yields under mild conditions. Imidazole, benzimidazole, carbazole, 2-methylindole, and benzotriazole were similarly N-alkylated in high yields by this method.
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