Fast low temperature ultrasonic synthesis and injection ready preparation of carrier free 17‐I‐123‐heptadecanoic acid

Abstract

Abstract 17‐I‐123‐heptadecanoic acid is prepared carrier‐free from 17‐Br‐heptadecanoic acid in methyl ethyl ketone at 100°C. A quantitative labeling yield is obtained within 20 minutes using a 50 KHz ultrasonic bath. Sonication allows the presence of water up to 7.5% v/v. The pattern shown by the plot of the kinetic curves is typical of two consecutive reactions: the first being the dissociation of a radioactive side product, the second a I − for Br nucleophilic exchange. The pure carrier‐free radioiodinated fatty acid is obtained by HPLC separation and is used clinically in a sterile 6% human serum albumine solution. The quality control of the injection ready solution is based on the use of a RP18 Sep‐Pak R cartridge.