Altered Frequencies of Dendritic Cells and <scp>IFN</scp>‐γ‐secreting T Cells with Granulocyte Colony‐Stimulating Factor (G‐<scp>CSF</scp>) Therapy in Acute‐on‐Chronic Liver Failure

Abstract

G-CSF therapy increased the frequencies of dendritic cells and reduced IFN-c secreting CD8 T cells with improved clinical severity indices. Decreased IFN- c production may contribute to reduced hepatocellular damage in ACLF patients.Our observations support the basis for further use of G-CSF therapy as immune modulator in these patients.