Antiinflammatory action of salicylates: aspirin is not a prodrug for salicylate against rat carrageenin pleurisy

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Life Sciences, Medicinal Chemistry, Pharmacology +10

Effects of Anti-inflammatory Drugs on Prostaglandin Biosynthesis

R.J. Flower, R Gryglewski, K. HERBACZŃSKA-CEDRO et al. · Nature New Biology · 1972 · 476 citations

Life Sciences, Biochemistry, Pharmacology +14

Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa

Brendan J.R. Whittle, G.A. Higgs, K.E. Eakins et al. · Nature · 1980 · 396 citations

Life Sciences, Immunology, Pharmacology +17

Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity.

G.A. Higgs, John A. Salmon, Brian E. Henderson et al. · Proceedings of the National Academy of Sciences · 1987 · 220 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +13

Modes of action of aspirin-like drugs.

Steven B. Abramson, Helen M. Korchak, R Ludewig et al. · Proceedings of the National Academy of Sciences · 1985 · 219 citations · Full text

Medicine, Immunology, Pharmacology +17