Vitamin D–Mediated Hypercalcemia in Slack Skin Disease: Evidence for Involvement of Extrarenal 25-Hydroxyvitamin D 1α-Hydroxylase

Abstract

Hypercalcemia associated with granulomatous slack skin syndrome seems to be caused by dysregulation of 1alpha-hydroxylase expression in both epidermal and dermal granulomatous cells. This contrasts with psoriasis and sarcoidosis of the skin, in which overexpression of the enzyme is restricted to keratinocytes and granulomata, respectively.