Investigation of sensory neurogenic components in a bleomycin‐induced scleroderma model using transient receptor potential vanilloid 1 receptor– and calcitonin gene‐related peptide–knockout mice

Abstract

These results suggest that activation of the TRPV1 receptor by mediators of inflammation induces sensory neuropeptide release, which might exert protective action against fibrosis. We confirmed the protective role of CGRP in the development of cutaneous sclerosis.