Synthesis of new chromeno-annulated <i>cis</i>-fused pyrano[3,4-<i>c</i>]pyran derivatives <i>via</i> domino Knoevenagel–hetero-Diels–Alder reactions and their biological evaluation towards antiproliferative activity

Abstract

A new series of chromeno-annulated cis -fused pyrano[3,4- c ]pyran derivatives have been prepared and evaluated for their anti-proliferative activity against human cancer cell lines.