<i>In Vitro</i> Transport and Partitioning of AL-4940, Active Metabolite of Angiostatic Agent Anecortave Acetate, in Ocular Tissues of the Posterior Segment

Abstract

The thin RPE-choroid layer contributes significantly to resistance to drug transport, and diffusivity in this layer is 10 times less than in sclera. This experimental scheme is proposed as an important component for the development of a general ocular physiologically based pharmacokinetic model.