Resistance to Phenobarbital Extends to Phenytoin in a Rat Model of Temporal Lobe Epilepsy

Abstract

The AED-resistant rats of our model meet the definition of pharmacoresistance in animal models, that is, persistent seizure activity not responding to at least two AEDs at maximum tolerated doses. This new model of pharmacoresistant TLE may be useful in the targeted development of new therapies for refractory epilepsy.