Acta Crystallographica Section C Crystal Structure Communications · 1995 · 13 citations · 0 references
MedicineMedicinal ChemistryPharmacologyNeuropharmacologyOrganic ChemistryStructure-activity RelationshipsHydration EffectsHydrogen Bonding In BiomoleculesLigand BindingSerotonergic PharmacologySerotonergic SignalingStructure-activity Relationship Analysis5-Hydroxytryptamine 3 Receptor Antagonists5-Hydroxytryptamine Receptor PharmacologyHydrogen-bond NetworksImidazole ChemistrySerotonin Receptor PharmacologySerotonin ReceptorsWater-mediated Hydrogen BondsWater-mediated Interactions In Receptors
The methyl substituted imidazole ring in the title compound, 2-methyl-1-(9-methyl-4-oxo-2,3,4,9-tetrahydro-1H-carbazol-3-yl) imidazol-3-ium chloride dihydrate, C18H20N3O+.Cl-.2H2O, is approximately perpendicular to the carbazole plane [dihedral angle 87.0(1) degrees]. The water molecules are involved in an elaborate network of hydrogen bonds that reinforce the stability of the dihydrate and the cohesion of the structure.