EFFECTS OF HUMAN GROWTH HORMONE IN MAN *

Abstract

Beck, McGarry, Dyrenfurth and Venning (1) first demonstrated activity of purified monkey and human pituitary growth extracts in man and this observation has been confirmed by Ikkos, Luft and Gemzell (2), Raben (3), Pearson, Lipsett, Greenberg and Ray (4), Henneman and Bergenstal and their co-workers (5, 6) and others (7).Studies in man have employed pituitary growth extracts prepared by the methods of Raben (8), Wilhelmi, Fishman and Russell (9) and Li and Papkoff (10).This paper summarizes balance and clinical data from 10 patients treated for 1 day to 24 months with the Raben preparation of human growth hormone (HGH). METHODSPituitary glands were collected at autopsy,' stored in cold acetone, and extracted by Dr. Maurice Raben (8).2