Heterocycles · 1989 · 11 citations · 0 references
Natural SciencesChemistryMedicinal ChemistryBioorganic ChemistryDrug DiscoveryOrganic ChemistryAntibiotic ProductionHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsOrganic SynthesisBioactive HeterocyclesHeteroaromatic Ring ConstructionHeterocyclic Medicinal ChemistryIsoquinoline Synthesis
An isoc~umarln tricyclic ester related to rings ABC of the title compound has been synthesized.he possibility of exchanging the heterocyclic oxygen atom for nitrogen and of using an ester group for the construction of the side c h a m has been checked on a model compound.Fredericamycm A l, produced by a strain of Streptomyces grlseus.1s an antiturnour antibiotic.The molecule presents an unusual heterocyclic system cyclopent~g]isoquinol~ne (rings ABC).