Age and Ageing · 1985 · 27 citations · 0 references
MedicineBiochemistryGeriatric MedicineMusculoskeletal MedicineOlder Adult Injury PreventionRenal PathophysiologyAge-related Muscle LossMuscle PathologyMuscle WeaknessRenal ImpairmentCreatine Kinase-mbIsoenzyme AnalysisMuscle DamageMuscle Enzyme TestingMuscle InjuriesSerum Creatine Kinase AssessmentSkeletal Muscle Physiology
Ten patients (mean age 85 years) had elevation of serum creatine kinase and other enzyme levels when admitted to hospital after falling at home and lying on the floor. No patient had definite clinical evidence of muscle injury but isoenzyme studies showed that the creatine kinase originated from skeletal muscle. A high ratio of peak creatine kinase to aspartate transaminase levels also helped distinguish skeletal from cardiac muscle damage. Several patients had minor disturbance of renal function and one developed acute renal failure.