IGF2 knockout mice are resistant to kainic acid-induced seizures and neurodegeneration

Insulin-like growth factors and their binding proteins: biological actions

J. I. Jones · Endocrine Reviews · 1995 · 2.1K citations

Life Sciences, Endocrinology, Molecular Biology +14

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

Thomas M. DeChiara, Argiris Efstratiadis, Elizabeth J. Robertsen · Nature · 1990 · 1.7K citations

Medicine, Genetics, Molecular Genetics +13

Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons

Klaus D Beck, Lyn Powell-Braxtont, H. R. Widmer et al. · Neuron · 1995 · 636 citations

Life Sciences, Neurobiology, Neuroscience +10

Differential expression of insulin-like growth factor genes in rat central nervous system.

Peter Rotwein, Susan K. Burgess, Jeffrey Milbrandt et al. · Proceedings of the National Academy of Sciences · 1988 · 477 citations

Life Sciences, Developmental Biology, Neuroscience +11

A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury

Peter D. Gluckman, Nicolin D. Klempt, Jian Guan et al. · Biochemical and Biophysical Research Communications · 1992 · 380 citations

Medicine, Neurobiology, Neuroscience +14