The reduced folate carrier in L1210 murine leukemia cells is a 58-kDa protein

A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells.

Katharine H. Dixon, Brendan C. Lanpher, Jason Chiu et al. · Journal of Biological Chemistry · 1994 · 242 citations · Full text

Life Sciences, Biochemistry, Cell Biology +12

Isolation of Human cDNAs That Restore Methotrexate Sensitivity and Reduced Folate Carrier Activity in Methotrexate Transport-defective Chinese Hamster Ovary Cells

So C. Wong, Susan A. Proefke, Alok Bhushan et al. · Journal of Biological Chemistry · 1995 · 190 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Defective Transport Is a Common Mechanism of Acquired Methotrexate Resistance in Acute Lymphocytic Leukemia and Is Associated With Decreased Reduced Folate Carrier Expression

Richard Görlick, Erdem Göker, Tanya Trippett et al. · Blood · 1997 · 186 citations · Full text

Medicine, Cancer Biology, Pharmacology +15

A Structurally Altered Human Reduced Folate Carrier with Increased Folic Acid Transport Mediates a Novel Mechanism of Antifolate Resistance

Gerrit Jansen, Robert Mauritz, Stavit Drori et al. · Journal of Biological Chemistry · 1998 · 163 citations · Full text

Medicine, Oncology, Pharmacology +15

Characterization of a Mutation in the Reduced Folate Carrier in a Transport Defective L1210 Murine Leukemia Cell Line

Kevin E. Brigle, Michael J. Spinella, Esteban E. Sierra et al. · Journal of Biological Chemistry · 1995 · 129 citations · Full text

Medicine, Molecular Biology, Pharmacology +15