Platelet Aggregation Inhibitors from the Seeds of<i>Swietenia mahagoni</i>: Inhibition of<i>in vitro</i>and<i>in vivo</i>Platelet-Activating Factor-Induced Effects of Tetranortriterpenoids Related to Swietenine and Swietenolide

Abstract

The ether extract from the seeds of Swietenia mahagoni Jacq. (Meliaceae) was found to inhibit platelet-activating factor (PAF)-induced platelet aggregation. Systematic separation of the extract afforded twenty eight tetranortriterpenoids related to swietenine and swietenolide. Among them, several new compounds, named swietemahonin A, D, E, and G and 3-O-acetylswietenolide and 6-O-acetylswietenolide, showed a strong inhibition against PAF-induced aggregation in vitro and in vivo assays.