New enkephalinase inhibitors as probes to differentiate “enkephalinase” and angiotensin-converting-enzyme active sites

Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids

David W. Cushman, H.S. Cheung, Emily F. Sabo et al. · Biochemistry · 1977 · 901 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

B P Roques, M C Fournié-Zaluski, E. Soroca et al. · Nature · 1980 · 707 citations

Medicine, Neuroscience, Pharmacology +10

High-affinity enkephalin-degrading peptidase in brain is increased after morphine

Bernard Malfroy, Jean-Paul Swerts, Anne Guyon et al. · Nature · 1978 · 650 citations

Medicine, Neuroscience, Pharmacology +12

Rational design of enkephalinase inhibitors: Substrate specificity of enkephalinase studied from inhibitory potency of various dipeptides

Catherine Llorens‐Cortés, G. Gacel, Jean-Paul Swerts et al. · Biochemical and Biophysical Research Communications · 1980 · 93 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

In vivo potentiation of [D-ALA2]met-enkephalin amide central effects after administration of an enkephalinase inhibitor

Sergio Algeri, Miriam Altstein, G. Simone et al. · European Journal of Pharmacology · 1981 · 29 citations

Medicine, Pharmacology, Pharmacotherapy +5