The enhanced anti‐cancer effect of hexenyl ester of 5‐aminolaevulinic acid photodynamic therapy in adriamycin‐resistant compared to non‐resistant breast cancer cells

Abstract

ALA-hx PDT more potently produced intracellular ROS in MCF-7/ADR cells, which might be due to down-regulation of Nrf2-mediated anti-oxidant gene transcription and up-regulation of PpIX synthesis via the induction of CPO and PPO. These findings suggest that ALA-hx PDT may be usable as a therapeutic alternative for adriamycin-resistant breast cancer.