Concepedia

Enantioselective Syn-Selective Scandium-Catalyzed Ene Reactions

David A. Evans, Jimmy Wu

Journal of the American Chemical Society · 2005 · 103 citations · 10 references

DOI

Concepts

Abstract

An enantio- and diastereoselective carbonyl-ene reaction catalyzed by chiral scandium pyridyl bis(oxazoline) (pybox) complexes has been developed. Uniformly high enantiomeric excesses and good yields were observed. Use of trisubstituted olefins generated the syn product in high enantio- and diastereoselectivity.

References

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