PubMed · 1965 · 114 citations · 0 references
Life SciencesInfectious DiseasesMicrobiologyMedical MicrobiologyMolecular VirologyVirologyAnimal VirusesPathogenesis Of Infectious DiseaseViral InfectionsViral PathogenesisViral PathologyCytopathic EffectsPathogen InfectivityPrimate Infectious DiseasesViral CultivationViral CultureViral Cytopathic EffectViral Cytopathology
SummaryRecently isolated strains of rubella virus as well as a stock strain regularly induce characteristic, easily recognized, cyto-pathic changes when adapted to a line of African green monkey cells established in this laboratory. The reaction of this cell line to infection provides a reliable and convenient means for titration of viral infectivity and assay of specific virus-neutralizing antibody.The author acknowledges the helpful guidance of Dr. John F. Enders in preparation of this manuscript.