Concepedia

Arguside A: A New Cytotoxic Triterpene Glycoside from the Sea Cucumber <i>Bohadschia argus</i><scp>Jaeger</scp>

Baoshu Liu, Yanghua Yi, Ling Li, Shilong Zhang, Hua Han, Yiyi Weng, Min-Xiang PAN

Chemistry & Biodiversity · 2007 · 35 citations · 10 references

DOI

Concepts

Abstract

A new holostane-based triterpene glycoside, arguside A (1), was isolated from the sea cucumber Bohadschia argus, collected in the South China Sea. The structure of the new compound was elucidated by spectroscopic and mass-spectrometric analyses, in combination with chemical transformations. Compound 1 exhibited significant cytotoxicity against different human tumor cell lines, being more active towards HCT-116 cells (IC50 = 0.14 microM) than 10-hydroxycamptothecin (HCP) used as positive control.

References

10

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

Philip Skehan, Ritsa Storeng, Dominic A. Scudiero et al. · JNCI Journal of the National Cancer Institute · 1990 · 9.8K citations

, , +10

Two New Cytotoxic and Virucidal Trisulfated Triterpene Glycosides from the Antarctic Sea Cucumber <i>Staurocucumis liouvillei</i>

Marta S. Maier, Alejandro J. Roccatagliata, Anabel Kuriss et al. · Journal of Natural Products · 2001 · 135 citations · Full text

, , +10

Toxins from sea cucumbers (holothuroids): chemical structures, properties, taxonomic distribution, biosynthesis and evolution.

Valentin A. Stonik, Vladimir I. Kalinin · PubMed · 1999 · 114 citations

, , +14

A Screening Method for Antimitotic and Antifungal Substances Using Conidia of Pyricularia oryzae, Modification and Application to Tropical Marine Fungi.

Hisayoshi Kobayashi, Michio Namikoshi, Takeshi Yoshimoto et al. · The Journal of Antibiotics · 1996 · 98 citations · Full text

, , +17

Cytotoxic and Antifungal Triterpene Glycosides from the Patagonian Sea Cucumber <i>Hemoiedema </i><i>s</i><i>pectabilis</i>

Hugo D. Chludil, Claudia Muniaı́n, Alicia M. Seldes et al. · Journal of Natural Products · 2002 · 92 citations

, , +15