Chemical and Pharmaceutical Bulletin · 2007 · 10 citations · 7 references
PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryStructure-activity RelationshipsAntibacterial PharmacologyLead Compound DesignLigand-based DesignPotency OptimizationQuantitative Structure-activity RelationshipsStructure-activity Relationship AnalysisAntibacterial Drug DevelopmentAntimicrobial Drug DevelopmentChemical Structure-activity RelationshipsMedicinal Chemistry ApplicationsNovel Antibacterial AgentsNovel Antibacterial Drug DiscoveryOxazole ChemistryOxazolidinone Antibiotics
Urea and thiourea derivatives of oxazolidinones were synthesized and their inhibitory activity (MIC) was determined on the bacterial strains which includes clinical isolates and quality control organisms. The structure activity relationships were studied and a 3D-QSAR model was built using Genetic Function Approximation. Interestingly found that electron withdrawing groups at the ortho position of the phenyl ring enhances the activity.
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Natesan Selvakumar, Deekonda Srinivas, Manoj Kumar Khera et al. · Journal of Medicinal Chemistry · 2002 · 70 citations