Journal of Oral Pathology and Medicine · 2005 · 73 citations · 44 references
Life SciencesInfectious DiseasesOral PathologyImmunogeneticsOral ImmunologyVirologyHistocompatibilityHla MatchingHla TypingOral InfectionsOral Viral InfectionsViral HepatitisGeographic Heterogeneity AnalysisHepatitis C InfectionHigh-resolution Hla TypingHla Allele PolymorphismHla Polymorphism AnalysisImmunogenetic SusceptibilityMolecular Hla TypingPopulation Hla Frequency Analysis
BACKGROUND: The association between hepatitis C virus (HCV) and oral lichen planus (OLP) is more common in the Mediterranean area and Japan, possibly because of immunogenetic factors. METHODS: Intermediate-resolution HLA-DRB typing by hybridization with oligonucleotide probes was performed in 31 Italian OLP patients with HCV infection, in 45 Italian OLP and in 48 British OLP patients without HCV infection. As healthy controls we included data from 145 unrelated Italian and 101 unrelated British bone marrow donors. RESULTS: Italian HCV+ve OLP patients possessed the HLA-DR6 allele more frequently than Italian and British OLP patients without HCV infection (51.6% vs. 17.7% vs. 16.7%; P corrected = 0.028 and 0.017, respectively). There was no difference in the frequency of the HLA-DR6 allele between Italian and British control subjects. CONCLUSIONS: The present data suggest that HLA-DR6 may be responsible for the peculiar geographic heterogeneity of the association between HCV and OLP.
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Influence of MHC class II genotype on outcome of infection with hepatitis C virus
Mark Thursz, Rhiannon Yallop, Robert Goldin et al. · The Lancet · 1999 · 286 citations