Annals of the New York Academy of Sciences · 2007 · 19 citations · 6 references
MedicineImmunologyOphthalmologyAutoimmunityOcular DiseaseOcular ImmunologyAutoantibodiesAutoimmune DiseasesAutoimmune Ocular DiseaseDry Eye DiseaseSjogren SyndromeSjögren SyndromeAnti-ssa AntibodiesAntibodiesSjögren Syndrome - Related Dry EyeSjögren Syndrome BiomarkersSjögren Syndrome DiagnosisSjögren Syndrome DiagnosticsSjögren Syndrome-related Dry EyeSjögren's Syndrome Biomarkers
The significance of antibodies against alpha-fodrin compared to antibodies against Ro (SSA) as markers of Sjögren's syndrome has been controversially discussed. We therefore compared the association of alpha-fodrin and Ro antibodies with dry eyes and dry mouth in the general population. In 168 "normal" participants, the prevalence of IgA antibodies against alpha-fodrin was 5% and of IgG antibodies against alpha-fodrin was 3%. IgA antibodies against alpha-fodrin were present in 3 of 4 and IgG antibodies against alpha-fodrin in 2 of 4 participants with the combination of dry eyes and dry mouth (P = 0.0002 and 0.005). Only one participant had antibodies against Ro and had dry eyes but normal saliva production. Antibodies against alpha-fodrin are associated with sicca syndrome and may be valuable diagnostic markers in patients with Sjögren's syndrome lacking Ro antibodies.
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Identification of α-Fodrin as a Candidate Autoantigen in Primary Sjögren's Syndrome
Norio Haneji, Takanori Nakamura, Koji Takio et al. · Science · 1997 · 405 citations
Life Sciences, Immunology, Pathology +14
α-Fodrin autoantibodies in the differential diagnosis of MS and Sjogren syndrome
de Sèze, Sylvain Dubucquoi, A.L. Fauchais et al. · Neurology · 2003 · 23 citations
Life Sciences, Immunology, Neurology +17