Meta-arylation of calixarenes using organomercurial chemistry

Abstract

A direct mercuration reaction combined with a subsequent Pd-catalyzed arylation was used to introduce the aryl moiety into the meta position of the calix[4]arene skeleton. The application of organomercurial intermediates thus allows the straightforward formation of meta-aryl-substituted derivatives representing a unique substitution pattern in calixarene chemistry.