A novel and efficient method for the olefination of carbonyl compounds with Grignard reagents in the presence of diethyl phosphite

Abstract

The widely available carbonyl compounds react with Grignard reagents in the presence of diethyl phosphite to give the corresponding olefins in good to excellent yields: A range of conjugated dienes, terminal olefins, multisubstituted-alkenes and conjugated enynes could be readily obtained by the method in mild conditions.