Gap junctions between the oocyte and companion follicle cells in the mammalian ovary.

TLDR

Follicle cell–oocyte gap junctions are implicated in regulating meiosis and luteinization. Tracer and freeze‑fracture microscopy revealed gap junctions between follicle cells and oocytes in neonatal rat, adult mouse, rat, rabbit, and primate ovaries, located at the ends of follicle cell projections traversing the zona pellucida and often associated with macula adherens junctions.

Abstract

Tracer and freeze-fracture electron microscopy of the ovaries of neonatal rat and adult mouse, rat, rabbit, and primate have revealed the presence of gap junctions between follicle cells and oocytes. The junctional connections are found at the ends of follicle cell projections which traverse the zona pellucida and terminate upon microvilli and evenly contoured nonmicrovillar regions of the oolemma. Gap junctions are often seen associated with a macula adherens type of junction. The gap junctions occasionally consist of minute ovoid plaques, but nore frequently appear as rectilinear single- or multiple-row aggregates of particles on the P-face or pits on the E-face. The functional significance of follicle cell-oocyte gap junctions is discussed with respect to the regulation of meiosis and luteinization.